Innovative reproductive technologies: risks and responsibilities

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Innovative reproductive technologies: risks and responsibilities.

In view of the global burden of subfertility, efforts are required to make assisted reproduction more effective, less burdensome and more equally accessible. New reproductive technologies are frequently introduced in clinical practice without a sound evaluation of their efficacy, effectiveness and/or safety. Safety issues in this context refer both to patients (mostly women) undergoing the rele...

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Genetic causes have a considerable involvement in infertility. Well-known examples are some chromosomal translocations or sex-chromosomal abnormalities and Y-chromosome deletions. The most common chromosomal aberrations associated especially with severe oligo- and azoospermia are sex chromosome aneuploidies and chromosomal translocations. Consequently, occurrence of aneuploid embryos will lower...

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Recently, a series of case reports and small studies has suggested that births involving assisted reproductive technology (ART) may have an increased risk of imprinting disorders such as Beckwith-Wiedemann syndrome and Angelman syndrome. Herein, the significance and implications of these findings are discussed. It is speculated that, although such imprinting disorders may be shown to be only ra...

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ژورنال

عنوان ژورنال: Human Reproduction

سال: 2011

ISSN: 0268-1161,1460-2350

DOI: 10.1093/humrep/der112